Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone.

Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.

The epithelial differences between the normal stomach (six subjects) and 47 patients with gastric ulcers were compared. The concentrations of intraepithelial lymphocytes and polymorphonuclear leucocytes in lesser curve and prepyloric gastirc ulcers were compared, the effect of treatment with carbenoxolone sodium was studied. There is a statistically significant reduction in the total number of ...

Treatment of Gastric Ulcer with Carbenoxolone Sodium and Oestrogens.

Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects.

A controlled trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer.

Carbenoxolone sodium is an effective agent promoting the healing of chronic gastric ulcers (Doll, Hill, Hutton, and Underwood, 1962; Doll, Hill, and Hutton, 1965; Horwich and Galloway, 1965; Turpie and Thomson, 1965). The drug is readily absorbed from the stomach and is largely excreted in bile (Iveson, Parke, and Williams, 1966). It is believed to have a local effect on the gastric mucosa thro...

Side effects of carbenoxolone sodium: a study of ambulant therapy of gastric ulcer.

Hypertension, oedema, or serious potassium loss has been reported in up to 50% of patients receiving carbenoxolone sodium, 300 mg. daily, for the treatment of gastric ulcer (Doll, Hill, Hutton, and Underwood, 1962; Doll, Hill, and Hutton, 1965; Turpie and Thomson, 1965; Horwich and Galloway, 1965). According to Turpie and Thomson's observations on 10 patients, these side effects can also occur ...